Which symptom is most often reported when APMV-1 (Newcastle’s disease) infects a human?

• A. None; this is not a zoonotic disease.
• B. Conjunctivitis
• C. Mild respiratory signs
• D. Potentially life threatening illness, predominately respiratory symptoms, although diarrhea can also be seen

Answer: (B)

Newcastle disease virus can infect humans, but human infections are uncommon and most often involve the eye. When exposed, the virus tends to cause conjunctival involvement rather than a primary respiratory or systemic illness. The eye becomes inflamed, leading to redness, tearing, irritation, and sometimes lid swelling—these are the findings most frequently reported in human cases.

While some infected people may experience mild respiratory symptoms or even more rarely more severe illness, these are not the typical or most common presentation. The choice describing conjunctivitis best matches the usual human manifestation after exposure to the virus.